"It's such a close knit community I think it has affected everybody. The death is not being treated as suspicious.". The BBC is not responsible for the content of external sites. ", She thanked the officers who arrived to the scene "in such a difficult situation" and added: "While understandably worrying and upsetting, this is believed to be an isolated incident in which those involved were known to one another and nobody else is being sought in connection with the deaths.". It is home to Sheffield Wednesday and Sheffield United football clubs and the Crucible Theatre is home to the World Snooker Championships. Researchers from the University of Sheffields Institute of Translational Neuroscience have discovered how to prevent the death of nerve cells and protect nerves from neurodegeneration in the most common forms of MND and frontotemporal dementia, The researchers used a peptide, a small assembly of amino acids or protein bricks, with a cell-penetrating module to stop mutant repeated RNA molecules being transported from the cell's nucleus to the cytoplasm where they are used to produce toxic repeat proteins which lead to the death of nerve cells, Findings of the study suggest the peptide could be given orally in a non-invasive manner - for example through a nasal spray which could be developed to enter the brain, The ground-breaking concept of using peptides to block the nucleus-to-cytoplasm transport of the damaging repeat expanded RNA could transform how some neurodegenerative conditions, which currently have no cure, are treated. The BBC is not responsible for the content of external sites. 2023 BBC. Copy Citation. "We don't know the details of the incident but it is imperative that families who come from Afghanistan are given all the support they need and housed in appropriate accommodation. A man was found unconscious in Pond Street. A woman has been found dead at a flat in Sheffield after officers forced entry to the property. MND and FTD are devastating diseases which currently have no cure. Join us on Twitter. Enquiries are ongoing and he remains in police custody at this time. Scientists have found a novel way to block the transportation of mutant RNA and subsequent production of toxic repeat proteins which lead to the death of nerve cells in the most common subtypes of MND and FTD. MND is a debilitating condition that destroys the cells that control movement, leaving sufferers unable to move, walk, talk and eventually breathe. 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One of the mothers had tears in her eyes after lighting a candle. In a statement, South Yorkshire Police said: "Shortly after 3am this morning (6 November), a man was discovered unconscious in Pond Street, Sheffield. Sheffield John Richard CROOKS Of Kingston Upon Hull Passed away peacefully on 13th November 2022, aged 75 5 Death Notice 900 29/11/2022 Sheffield "As a council we are in close contact with the police and will provide any support that we can to the family - my heart goes out to them.". Killamarsh is a community in mourning and disbelief, according to the Rev Canon Helen Guest, rector at St Giles Church. 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The council will be renewing its nine Public Space Protection Orders until 2026. This study was made possible thanks to donated tissue samples from the skin of MND patients which were reprogrammed into nerve cells. Owls full-back Johnson given three-match ban. news@thestar.co.uk. FamilySearch. "We can't believe this tragedy has happened in our community and it's literally a stone's throw from where I live," she said. Download the YorkshireLive app to customise the news that matters to you and get the latest updates first. This groundbreaking concept of using peptides to block the effects of the damaging repeat expanded RNA and toxic repeat proteins could transform how some neurodegenerative conditions which currently have no cure are treated. South Yorkshire Police have confirmed that emergency services were called to High The man, who worked as an interpreter for the British Army in Afghanistan, said one of his children alerted him to the boy falling and he went outside to help. FTD occurs when nerve cells in the frontal and temporal lobes of the brain are lost, causing the lobes to shrink. "The police are providing support to the family while the investigation continues and we cannot comment further at this time. Send your story ideas to yorkslincs.news@bbc.co.uk. Promising MND drug helps slow disease progression and benefits patients physica. John Paul and Lacey's father Jason Bennett said "life will never be the same again", Lacey and John Paul's mother Terri Harris was found dead at the house, Local residents have been lighting candles at St Giles Church, Specially-trained officers are liaising with the families of the deceased, Flowers have been left near the police cordon on Chandos Crescent, People started gathering for a candlelit vigil in the local park earlier on Monday night, Mourners also left flowers and teddies alongside the candles. The 16 most up-and-coming areas in Sheffield according to census, including Devonshire Green and Park Hill News Take a look at our new and improved A man has tragically died after his car came off the road in a horror crash in Sheffield's city centre. Database with images. "Each one of you is here to remember four people who are no longer with us," he said. Join us on Facebook. S1 2GU. A woman has been found dead at a flat in Sheffield after officers forced entry to the property. Call 101, quoting incident number 853 of December 9 or Crimestoppers on 0800 555 111. They are vulnerable and often very traumatised.". A fellow Afghan staying in the hotel said Mohammed's family arrived in the UK 15 days ago. Chief Constable Rachel Swann described the deaths as a "shocking event". The force has appealed for anyone who witnessed the incident to contact them. It is reported Mohammed Munib Majeedi fell from a ninth-floor room where he was staying with his mother. Professor Guillaume Hautbergue, Professor of Translational RNA Biology at the University of Sheffield, who led the study said: When we tested our innovative approach by adding the peptide to the food eaten by fruit flies not only did the peptides block the damaging mutations which cause MND and FTD from being transported to the cell's nucleus, we actually saw an improvement in their neurofunction. In a message posted on Facebook earlier, he said "life will never be the same". Scientists discover how to prevent death of nerve cells in most common forms of MND and dementia Researchers from the University of Sheffields Institute of Jin Wang took over KH Oriental from his own father who founded Sheffields largest Chinese supermarket on London Road in 1976. Though police have not confirmed how the woman died, witnesses have reported seeing her "on fire" in the park and a cordon was in place while police conducted their investigation. Both are due to appear before Sheffield Magistrates' Court on Saturday. Sarah Brierley died from serious head injuries, police say, Police forced entry into the flat on Monday morning. He had to drive home knowing he has lost his children. Traffic and Travel Yorkshire traffic recap for M62, M1, A1, A64, M18 including closures, accidents and roadworks Motorway traffic plus road closures, roadworks and what's happening in Bradford, Huddersfield, Leeds, York, Sheffield and To get the latest email updates from South Yorkshire Live, click here . Read about our approach to external linking. Manchester Road Records extracted by FindMyPast and images digitized by FamilySearch. Read about our approach to external linking. "It's really important we build as full a picture as possible of events leading up to the discovery of the woman's body this morning, so we want to hear from anyone living locally who may have seen, heard or noticed anything suspicious over the last few weeks.". Welcome back Edit Account-Sign Out. The Universitys four flagship institutes bring together our key strengths to tackle global issues, turning interdisciplinary and translational research into real-world solutions. Treatments are very limited and there is no cure. Derbyshire Police said they were called to the house at 07:26 BST on Sunday after concerns were raised about the safety of a man. Media contact: For more information please contact: Amy Huxtable, Media and PR Officer, University of Sheffield, 07568116781, a.l.huxtable@sheffield.ac.uk, A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export suppresses neurodegeneration. Scientists have found a novel way to block the transportation of mutant RNA and subsequent production of toxic repeat proteins which lead to the death of nerve cells in the most common subtypes of motor neurone disease (MND) and frontotemporal dementia (FTD). **Strictly embargoed until 19:00 (GMT) Wednesday 1 March 2023**, Scientists discover how to prevent death of nerve cells in most common forms of MND and dementia. Sheff Utd. Location (optional) Search. The Sheffield driver and his passenger both made gestures towards a speed camera van. Webnews, sport, business, politics and more, from Sheffield's newspaper, The Star. "I continue to appeal that anyone with information about Sarah's death gets in touch.". On Jan. 1, Dominique Anderson, 28, was shot to death in an early-morning disturbance on Kerstetter Way. WebCite This Collection. Hundreds of people from the Killamarsh community gathered at Baker Park near Chandos Crescent on Monday night for a vigil. 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Organiser David Taylor, who is a local pastor from Church on the Street, said it was "a dark day in the place I call home". "British Newspaper Archives, Obituaries." Office: 01-142-229-859, Copyright 2023 by the American Association for the Advancement of Science (AAAS), /Life sciences/Biochemistry/Biomolecules/, /Life sciences/Biochemistry/Biomolecules/Proteins/, /Life sciences/Biochemistry/Biomolecules/Proteins/Membrane proteins/, /Life sciences/Neuroscience/Cellular neuroscience/Neurons/, /Social sciences/Psychological science/Clinical psychology/Cognitive disorders/, Researchers from the University of Sheffields Institute of Translational Neuroscience have discovered how to prevent the death of nerve cells and protect nerves from neurodegeneration in the most common forms of MND and frontotemporal dementia, The researchers used a peptide, a small assembly of amino acids or protein bricks, with a cell-penetrating module to stop mutant repeated RNA molecules being transported from the cell's nucleus to the cytoplasm where they are used to produce toxic repeat proteins which lead to the death of nerve cells, Findings of the study suggest the peptide could be given orally in a non-invasive manner - for example through a nasal spray which could be developed to enter the brain, The groundbreaking concept of using peptides to block the nucleus-to-cytoplasm transport of the damaging repeat expanded RNA could transform how some neurodegenerative conditions, which currently have no cure, are treated. "She was screaming, 'my son, my son'. 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