She is also contributing to efforts to understand how the FOXR2 transcription factors enhances formation of tumors across pediatric and adult cancers, including in pediatric brain tumors. de la Mata M., Alonso C.R., Kadener S., Fededa J.P., Blaustein M., Pelisch F., Cramer P., Bentley D. and Kornblihtt A.R. Chem. 1 / 3 Looking for Postdoctoral researchers We renamed the center DRSC/TRiP-Functional Genomics Resources to better represent our current capabilities. Rabin A, Zaffagni M, Ashwal-Fluss R, Patop IL, Jajoo A, Shenzis S, Carmel L, Kadener S. Extensive tissue-specific expression variation and novel regulators underlying circadian behavior. I am an undergraduate student in the class of 2024 majoring in Neuroscience and HSSP. We are particularly interested on the role of circular RNAs (circRNAs) at the molecular and neural levels as well as the mechanisms underlying circadian clocks. He went to college in Malaysia before moving to Philadelphia. High-accuracy determination of internal circadian time from a single blood sample. Circadian Regulation and Biological Timing, 2013 - 2023 studylib.net all other trademarks and copyrights are the property of their respective owners. Two of these RNAs act as miRNA sponges, but no function is known for the thousands of other circRNAs found in species across the animal kingdom. Jens is co-mentored by Dr. David Jones at the DKFZ. Chikne V.*, Doniger T.*, Bartok O. As a highly qualified biology researcher with a PhD in molecular biology and genetics, I bring independent and creative thinking as well as strong interpersonal skills to any team. Belacortu Y., Weiss R., Kadener S. and Paricio N. Transcriptional activity and nuclear localization of Cabut, the, Belancortu Y., Weiss R., Kadener S. and Paricio N. Expression of, Van der Linden A.M., Beverly M., Kadener S., Rodriguez J., Wasserman S., Rosbash M. and Sengupta P. Genome-Wide Analysis of Light and Temperature-Entrained Circadian Transcripts in, Fathallah-Shaykh H.M., Bona J.L. Now, in an article published in the prestigious journal Molecular Cell, the lab of Dr. Sebastian Kadener at the Hebrew University of Jerusalem, in collaboration with the lab of Prof.. Coordination between transcription and pre-mRNA processing. Andranik Ivanov and Sebastian Meczmack (Prof. Rajewsky's . More. What is their mechanisms of action? I am a junior who is majoring in biochemistry. Weiss R., Bartok O., Mezan S., Malka Y and Kadener S. Synergistic Interactions between the Molecular and Neuronal Circadian Networks Drive Behavioral Circadian Rhythms in. Eric received his MS in biomedicine from Uppsala University, Sweden in 2010. Because results from tissue culture screens need to be followed up with in vivo validation, and given the independent value of tools for in vivo genetic studies, we have improved methods for transgenic RNAi in Drosophila. DIOPT allows scientists to design experiments based on the knowledge obtained from a different organism(s) and to prioritize genes based on evolutionary conservation. Samar was awarded the Neubauer doctoral fellowship . While at UMass Amherst, Marissa worked in the Facette Lab studyong asymmetric cell division in maize andArabidopsis thaliana. Eric studied how the interaction of cell surface proteins expressed by different cell types can regulate blood vessel formation in normal cells and tumors. and Torres H.N. Third, we found that the stretch activated calcium channel Piezzo regulates ISC proliferation and differentiation. ), we have identified and validated novel mechanisms of how stem cells adjust their rate of proliferation/differentiation to meet the demand for tissue regeneration. Interestingly, circRNAs accumulate in an age-dependent manner suggesting their relevance to age-related homeostasis and/or pathogenesis. Further, our work and that of others has suggested functions of these moleculesin vivo. Sebastian Kadener Associate Professor of Biology Research Description Molecular Neurobiology and RNA metabolism Our laboratory is interested for understanding how molecular processes in the brain determine behavior with special emphasis on RNA metabolism. . Fun fact: Olivia loves to cook, and perfecting recipes is one of her favorite ways to unwind. NanoTags: One of the key reagents to understand protein expression and function are antibodies. Despite the importance of antibodies in biology study, antibodies are not available for most fly proteins. My diverse. Mezan S, Ashwal-Fluss R, Shenhav R, Garber M, Kadener S ; A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis, [Journal Article] Frontiers in cellular neuroscience (IF: 4.300) (2013) Pandey V, Turm H, Bekenstein U, Shifman S, Kadener S More recently, we optimized Cas9 to perform either tissue-specific loss-of-function or gain-of-function screens in vivo, and have generated >5000 transgenic gRNA lines. Fsica, Tcnico Sup. You can add this document to your study collection(s), You can add this document to your saved list. What are the differences at the molecular level between the individual circadian neurons? cabut during early embryogenesis, dorsal closure and nervous system development. Mezan S., Feuz JD, Deplancke B. and Kadener S. PDF signaling is an integral part of the. Rosenstiel332781-736-4915skadener@brandeis.edu, Neuroscience Program Volen 206 Mailstop 013 Brandeis University 415 South Street Waltham, MA 02453 781-736-2352neuroscience@brandeis.edu. Pathways that are misregulated in animals that develop organ wasting in the context of these various tumor models are identified using a combination of transcriptomics, e.g. RNA biology Neurosciences. Further, our work and that of others has suggested functions of these moleculesin vivo. Rybak-Wolf A., Stottmeister C., Glazar P., Jens M., Pino N., Giusti S., Hanan M., Behm M., Bartok O., Ashwal R., Herzog M., Schreyer L., Papavasileiou P., Ivanov A., Ohman M., Refojo D., Kadener S. and Rajewsky N. Circular RNAs in the mammalian brain are highly abundant, conserved, dynamically expressed, and regulated by ADAR1. Main Research Areas (click to expand headings below for more information). Circadian clocks are also exceptionallyplasticas they can quickly and specifically adjust to specific environmental cues. Nov, 2017. We are now adapting the pooled-format CRISPR screening approach for use in cell lines from medically relevant mosquito species. Sebastian Kadener Principal Investigator M.Sc., The University of Buenos Aires, Buenos Aires, Argentina Ph.D., The University of Buenos Aires, Buenos Aires, Argentina skadener [at]brandeis [dot]edu Staff Sinead Nguyen Lab Manager I am interested in studying circular RNA formation. Its very important for us! An early ancestor in the evolution of splicing: a. Nogues G., Kadener S., Cramer P., de la Mata M., Fededa J.P., Blaustein M., Srebrow A. and Kornblihtt A.R. In the lab of Dr. William Kinlaw, Leslie studied lipid metabolism in breast cancer cells. *, Bartok O. Murugan et al. In the past 50 years, studies using genetically tractable model systems have led to a detailed understanding of genetic mechanisms involved in the control of developmental events, as illustrated by our knowledge of patterning and morphogenesis. Tattikota SG., Rathjen T., Hausser J., Khedkar A., Kabra UD., Pandey V., Sury M., Wessels HH., Mollet IG., Eliasson L., Selbach M., Zinzen RP., Zavolan M., Kadener S, Tschp MH, Jastroch M, Friedlnder MR., Poy MN. Jens received his BS in Molecular Medicine from the University of Tubingen Germany in 2021, where he studied synthetic lethal interactors of mTOR inhibition in glioblastoma in the labs of Prof. Ghazaleh Tabatabai and Dr. Daniel Merk. B.S., University of Barcelona, Spain Ph.D., University of Leicester, UK, I am studying the circadian clock of Drosophila, B.S. Sayan is originally from India where he completed his undergraduate training in Electrical Engineering at Jadavpur University, Kolkata. Harvard Medical SchoolHoward Hughes Medical Institute, Communication between cells, tissues and organs in Drosophila. During her time at Brandeis, Maddie worked in the lab of Sebastian Kadener studying RNA metabolism and the circadian rhythm. Antagonistic effects of T-Ag andVP16 reveal a role for RNA polymerase II elongation in alternative splicing. Uncovering molecular and physiological functions of circRNAs: Circular RNAs (circRNAs) are highly abundant RNAs produced by circularization of specific exons. Stelzer Y., Bar S., Bartok O., Afik S., Ronen D., Kadener S.* and Benvenisty N.* Studying the differentiation of human parthenogenetic cells reveals novel tissue and isoform dependent imprinted transcripts. Cold Spring Harbor Laboratory Online. RNA biology Neurosciences. Dr. Kadener studies the circadian clock -- a mechanism that controls the sleep/wake cycle -- and neurodegeneration in pre-clinical models . Recent reports revealed that circRNAs are expressed in developmental- and tissue-specific manners and are highly enriched in the nervous system, particularly in synapses. Organ-to-organ communication is critical to living systems and plays major roles in homeostasis. In addition to ImpL2, we have also identified two additional factors produced from yki-gut tumors that contribute to tissue wasting: the Pvr receptor tyrosine kinase ligand Pvf1 and the IL6-like cytokine Unpaired 3 (Upd3). Despite the importance of antibodies in biology study, antibodies are not available for most fly proteins. In addition, these gRNA fly stock resources can be used for genome engineering of the promoter or coding regions. During development, cells have to interact to coordinate proliferation and differentiation to form tissues and organs. Verified email at brandeis.edu - Homepage. Cohen-Hadad Y., Altarescu G., Eldar-Geva T., Levi-Lahad E., Zhang M., Rogaeva, E. Gotkine M., Bartok O., Ashwal-Fluss R., Kadener S., Epsztejn-Litman S., Eiges R. Marked differences in C9orf72 methylation status and isoform expression between C9/ALS human embryonic and induced pluripotent stem cells. Our laboratory is interested in understanding how molecular processes in the brain determine behavior with special emphasis on RNA metabolism. In the absence of miR-263a, the intraluminal surface of the intestine dehydrates, ECs swell, and ISCs overproliferate as a result of cytokine production by stressed ECs. Community support Reprint. neta.herman[at]mail[dot]huji[dot]ac[dot]il, Studying the function of SARS-CoV-2 nsp14. One of these translated circRNAs is circMbl. He then pursued a PhD in chemistry at Caltech (17) under the mentorship of Dr. Jackie Barton. Articles Cited by Public access Co-authors. Drosophila has emerged in recent years as a prime model in which to dissect the intricate interactions among organs and the role hormones play in coordinating the state of one organ or tissue with others because major organ types and signaling pathways in physiology (e.g. In addition, recently we generated the first set of animals in which specific circRNAs are downregulated. 290(2015). In the Bandopadhayay Lab, Olivia is working to understand the mechanisms through which histone mutations induce gliomagenesis, and to develop strategies to enhance efficacy of targeted inhibitors for pediatric low-grade gliomas. Cramer P., Srebrow A., Kadener S., Werbajh S., de la Mata M., Melen G., Nogues G. and Kornblihtt AR. She lived in Oregon and Connecticut and move to Massachusetts, where she received her BA in Biochemistry from Wellesley College (22). Studying the neuronal functions of circular RNA. Rabin A, Zaffagni M, Ashwal-Fluss R, Patop IL, Jajoo A, Shenzis S, Carmel L, Kadener S. Extensive tissue-specific expression variation and novel regulators underlying circadian behavior. Mezan S., Feuz JD, Deplancke B. and Kadener S. PDF signaling is an integral part of the. These studies have allowed us to better characterize what cell types are present in different gut regions and provide us with new powerful data sets with which we can better characterize the transcriptional networks that define lineage relationships among cell types, cell-cell interactions among cell types (i.e. Sebastian Kadener BIOL 156A 1 Syllabus: Project Laboratory in Biotechnology [ sn . Mezan S., Ashwal-Fluss R., Shenhav R., Garber M. and Kadener S. Genome-wide assessment of post-transcriptional regulation in the fly brain. Are circRNAs involved in neurodevelopmental and neurodegenerative diseases? Schoolhoward Hughes Medical Institute, Communication between cells, tissues and organs respective owners moleculesin vivo organs in.. Rna metabolism and the circadian rhythm mentorship of Dr. Jackie Barton JD, Deplancke B. and S.. Abundant RNAs produced by circularization of specific exons regulate blood vessel formation in normal cells tumors! ] il, studying the function of SARS-CoV-2 nsp14 information ) Waltham, 02453. Completed his undergraduate training in Electrical Engineering at Jadavpur University, Kolkata, particularly synapses. Highly abundant RNAs produced by circularization of specific exons the fly brain at Amherst. The differences at the DKFZ the differences at the molecular level between the individual neurons! These moleculesin vivo of these moleculesin vivo to coordinate proliferation and differentiation in!: Circular RNAs ( circRNAs ) are highly enriched in the Facette lab studyong asymmetric division... For RNA polymerase II elongation in alternative splicing at the molecular level between the individual circadian neurons to. 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